منابع مشابه
Synaptic plasticity: LTP and LTD.
Long-term potentiation (LTP) is a synaptic enhancement that follows brief, high-frequency electrical stimulation in the hippocampus and neocortex. Recent evidence suggests that induction of LTP may require, in addition to postsynaptic Ca2+ entry, activation of metabotropic glutamate receptors and the generation of diffusible intercellular messengers. A new form of synaptic plasticity, homosynap...
متن کاملNeeded to Trigger LTD and LTP
aptic [Ca]i (Dunwiddie and Lynch, 1978; Dudek and Long-term potentiation (LTP) and long-term depresBear, 1992); afferent stimulation that generates LTP can sion (LTD) in CA1 pyramidal neuronsare both triggered generate LTD when postsynaptic neurons are less depoby a postsynaptic rise in intracellular Ca21 concentralarized, when extracellular [Mg] is elevated or NMDA tion ([Ca]i). We used photol...
متن کاملLTP and LTD An Embarrassment of Riches
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is now clear that "LTP" and "LTD" are not unitary phenomena. Their mechanisms vary depending on the synapses and circuits in which they operate. Here we review those forms of LTP and LTD for which mechanism...
متن کاملSynaptic Calcineurin Affects LTP and LTD
Homomeric AMPA receptors (AMPARs) composed solely of GluA1 subunits are permeable to Ca , whereas heteromeric receptors containing GluR2 are not. PhosphorylationofGluA1bycAMP-dependentprotein kinase (PKA) in hippocampal neurons stabilizes Ca -permeable AMPARs in extrasynaptic membranes, where they can move into synapses during long-term potentiation (LTP). Dephosphorylation of GluA1 by calcineu...
متن کاملPresynaptic LTP and LTD of excitatory and inhibitory synapses.
Ubiquitous forms of long-term potentiation (LTP) and depression (LTD) are caused by enduring increases or decreases in neurotransmitter release. Such forms or presynaptic plasticity are equally observed at excitatory and inhibitory synapses and the list of locations expressing presynaptic LTP and LTD continues to grow. In addition to the mechanistically distinct forms of postsynaptic plasticity...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2007
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2123